Copley-Merriman C, Olanrewaju B, Hogue S. Systematic literature review of the temporal relationship between nsaid use and gastrointestinal, cardiovascular, or renal events. Poster presented at the 2013 ISPOR 18th Annual International Meeting; May 2013. New Orleans, LA. [abstract] Value Health. 2013 May; 16(3):A110.

Treatment of acute pain often includes use of nonsteroidal anti-inflammatory drugs (NSAIDs). Although effective, they are known to cause adverse events (AEs), including gastrointestinal, cardiovascular, and renal events. The objective of this review was to assess the temporal relationship between NSAID use and risk of gastrointestinal, cardiovascular, and renal AEs