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Cardiovascular diseases represent a significant factor contributing to morbidity and mortality in humans. Marked advancements have occurred in the development of novel therapeutics and procedures intended to improve cardiovascular functioning and reduce mortality rates. One area that continues to have limited diagnostic attention and, therefore, therapeutics is the spontaneous rhythmic contractions of the arterial walls that occur in synchrony with the heartbeat. Pulse synchronized contractions may represent an untapped opportunity for improvement in treatment of cardiovascular disorders. This paper reviews the essence of the literature on pulse synchronized contractions.